Stem Cells,
Information and prospects.

Where are stem cells located?

Stem cells are distributed in various tissues and stages of life. Some sources are present only once (at birth), while others are available even in adulthood. Each type has its own characteristics and limitations, which determine its clinical or experimental use.

In the embryonic phase

The embryonic stem cells (ESC) appear in the very first days after fertilization, within the blastocyst. They are pluripotent: they can give rise to any cell in the human body.

However, they cannot be harvested for clinical use: they are only accessible in basic research laboratories and, for ethical and legal reasons, are not used in therapy.

At birth: umbilical cord and placenta

The birth represents a unique moment to collect stem cells, available only once in a lifetime:

  • Cord blood – rich in hematopoietic stem cells, used in over 80 blood and immune system disorders.
  • Umbilical cord tissue – contains mesenchymal stromal cells (MSCs), studied for regenerative applications (cartilage, bone, muscle).
  • Placenta – a large reservoir of both hematopoietic and mesenchymal cells, with interesting prospects in immunology and oncology.

The collection of blood, tissue, and placenta is non-invasive, safe, and painless, for both the mother and the newborn.

In adult tissues

Even after birth, the body retains reserves of stem cells.

  • Bone marrow – the historical source of hematopoietic stem cells. The collection is invasive and requires anesthesia.
  • Peripheral blood (PBMC – peripheral blood mononuclear cells) – an accessible source through blood draw. PBMCs, if reprogrammed, become pluripotent iPSC cells, a cornerstone of future medicine.
  • Adipose tissue (SVF – Stromal Vascular Fraction) – obtained through minimally invasive procedures, provides mesenchymal cells studied for orthopedics and regenerative surgery.
  • Other tissues – muscles, skin, and brain contain stem cell niches with specific functions, but are not easily accessible.

Among adult sources, peripheral blood and adipose tissue offer simple and safe collections.

In the laboratory: the iPSCs

Thanks to cellular reprogramming, today we can create induced pluripotent stem cells (iPSC) starting from adult cells, such as PBMCs from peripheral blood.

iPSCs are an ethical alternative to embryonic cells and have already revolutionized research in biomedicine.

Comparative table of the main sources of stem cells

Cell phone source
Phase of life in which one gathers
Cell type
Possible uses
Ease of collection and security
Embryonic stem cells (ESC)
Days 5–7 post-fertilization (blastocyst)
Pluripotent
Basic research only, not clinical collection
❌ Non collectible
Cord blood
At birth
Hematopoietic
Consolidated transplants for over 80 hematological and immunological diseases
✅ Simple, non-invasive collection
Corded fabric
At birth
Mesenchymal
Experimental clinical studies (cartilage, bone, muscle)
✅ Simple, non-invasive collection
Placenta
At birth
Hematopoietic + mesenchymal
Research and perspectives in immunology, oncology, and regeneration
✅ Simple, non-invasive collection
Bone marrow
Adulthood
Hematopoietic
Consolidated transplants, historical collection
⚠️ Invasive collection (anesthesia)
Peripheral blood (PBMC)
Adulthood
Mononucleate → iPSC
Base for generating pluripotent iPSC cells; research and future clinical prospects
✅ Blood draw: safe, non-invasive
Adipose tissue (SVF)
Adulthood
Mesenchymal
Experimental applications in orthopedics and regenerative medicine
✅ Minimally invasive, safe procedure

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