n this experimental study, a protocol was developed for processing a formulation derived from secretome obtained from adipose tissue mesenchymal stem cells at different concentrations. Its molecular composition and in vitro efficacy was evaluated when applied to breast cancer cell lines. In addition, the ability of the formulation to suppress the growth of triple-negative breast cancer when infused into a mouse model of the disease was verified.
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Current therapies do not induce significant benefits in chronic stroke patients. Preclinical studies suggest that autologous transplantation of adipose tissue stem cells may be of benefit. This phase one clinical trial was developed to test the safety and efficacy of adipose tissue mesenchymal stem transplantation in chronic stroke patients.
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To date, the immunomodulatory capacity of mesenchymal stem cells is well known. In this phase one clinical trial, the efficacy of these cells for the treatment of refractory lupus nephritis (LN) was verified. Specifically, 9 patients received systemic infusion of mesenchymal stem cells derived from adipose tissue and followed up for a 12-month follow-up period.
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