Advanced cell therapies: three requirements for reaching the patient
Between a stored cell and a medicine lies a distance made of processes, controls and data. Advanced cell therapies only cover that distance when the product is reproducible, traceable and verified in a clinical study with pre-declared endpoints. A multicentre trial published in 2026 on umbilical cord mesenchymal cells, and the regulatory decision that followed […]
Microbiota in preterm infants and cord blood: what a twin-pair study teaches us
What happens to the microbiota in preterm infants when a baby is given back its own cord blood cells at birth? A randomised study measured exactly that, using an unusual design: comparing monozygotic twins, one treated with their own cells, the other with saline. In the treated infants a more balanced immune profile and a […]
Umbilical cord mesenchymal stem cells: results of a real-world study in 120 patients
Umbilical cord mesenchymal stem cells were assessed in a study carried out under real clinical practice conditions, which followed 120 patients with lupus nephritis unresponsive to conventional therapy for twelve months. Twelve months after infusion, 56.7% showed a positive renal response. The context: an autoimmune disease that targets the kidneys Systemic lupus erythematosus (SLE) is […]
Knee cartilage: comparing 2 cell-based therapies
Knee cartilage injuries are a difficult clinical problem because this tissue cannot repair itself. A phase I and II study directly compared two cell-based therapies: umbilical cord mesenchymal stem cells and the patient’s own bone marrow aspirate concentrate. The group treated with cord cells reported earlier pain relief and higher functional scores at 6 and […]
Cord Blood in Preterm Infants: What the 5-Year Follow-Up Shows
Cord blood collected at birth was the focus of a phase II trial that followed a group of very preterm infants for five years. The results, published in Stem Cells Translational Medicine, show significant differences in fine motor development and in the personal-social domain. It is one of very few studies in this field to […]
Cord Blood Stem Cells a treatment for stroke
CORD BLOOD STEM CELLS: AN IMPORTANT CELLULAR SOURCE FOR TREATING STROKE Stroke is today one of the major challenges for modern medicine, as our brain has a very limited natural ability to repair damage to nervous tissue. However, scientific research is opening a new and exciting frontier: the use of umbilical cord cells to regenerate […]
Umbilical Cord Stem Cells and GvHD: New Hope from a Clinical Trial
The Challenge of GvHD Graft-versus-host disease (GvHD) is one of the most serious complications of allogeneic stem cell transplantation.The acute, steroid-refractory form (aGvHD) is particularly dangerous, often life-threatening, and difficult to manage with conventional therapies. Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) MSCs are adult stem cells with strong immunomodulatory properties, able to regulate immune activity […]
Pulmonary Fibrosis: New Perspectives from Nebulized Umbilical Cord Stem Cell-Derived Extracellular Vesicles
Pulmonary fibrosis is a chronic, progressive disease characterized by abnormal thickening of lung tissue, severely impairing breathing. Current therapies are limited: they can only slow progression but do not address the root cause.A new approach using extracellular vesicles (EVs) derived from umbilical cord mesenchymal stem cells (hUC-MSC-EVs) administered via nebulization offers promising prospects for more […]
Systemic Lupus Erythematosus: New Perspectives from Umbilical Cord Stem Cells
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which the immune system attacks healthy tissues, causing inflammation and damage to multiple organs.Current therapies aim to control symptoms and prevent flare-ups, but they are not always effective for every patient.Recent research has focused on innovative strategies, including the use of the secretome derived from […]
Umbilical Cord Stem Cells: A New Frontier in Treating Aging Frailty
With the rise of life expectancy, aging frailty has become a global healthcare challenge. It is a complex condition marked by reduced physiological reserve, muscle loss and weakness, and greater vulnerability to external stressors. To date, there are no approved drugs for this syndrome: current approaches are limited to nutrition programs and physical exercise. A […]
